Marvel vs Capcom 4 is a sequel to Ultimate Marvel vs Capcom 3 adding the Marvel Characters added in Injustice: The Unavenged as well as 20 new Capcom characters for a total of 90 characters. New additions include:
| Marvel | Capcom |
|---|---|
| Namor | Tigrex (Monster Hunter) |
| Juggernaut | Batsu Ichimonji (Rival Schools) |
| Carnage | Jedah (Darkstalkers) |
| Elektra | Poison (Final Fight) |
| Daredevil | Akira Kazama (Rival Schools) |
| Green Goblin | Nero (Devil May Cry) |
| Human Torch | Asura (Asura's Wrath) |
| Black Panther | Soki (Onimusha) |
| Ms. Marvel | Seneschal (Dragon's Dogma) |
| Punisher | Megaman |
| Black Widow | Regina (Dino Crisis) |
| Doctor Octopus | Sigma (Megaman X) |
| Emma Frost | Baby Bonnie Hood (Darkstalkers) |
| Scarlet Witch | Tessa (Red Earth) |
| Mephisto | Gene (God Hand) |
| Nebula | Devilotte (Cyberbots) |
| Anti-Venom | Fou Lu (Breath of Fire) |
| Silver Surfer | Gill (Street Fighter III) |
| Thanos | M. Bison (Street Fighter) |